GEMINI STUDY: A Phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide (Aubagio®) in participants with relapsing forms of multiple sclerosis

The Neurology team who screened a further 2 patients for the Gemini 2 trial this month which is trialling Tolebrutinib in Relapsing- remitting MS patients.

HERCULES STUDY: A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with non-relapsing secondary progressive multiple sclerosis

This month the Neurology team have recruited their first Hercules trial patient. This study is trialling Tolebrutinib in secondary progressive MS patients.

GenOMICC: A personal thanks to Exeter research team from Chief Investigator:

‘Many people have contributed to the GenOMICC study, but I wanted to thank you specificallyf or your outstanding personal contribution. Because of the tireless work from you and your team, Royal Devon and Exeter Hospital have recruited 105 (now up to 116) patients in the last 18 months, during the extremely difficult circumstances of the pandemic. I know how hard this is to achieve, particularly with all the additional challenges of extra research work, staff absences, PPE and the risks to your own health.’

‘Thanks to your efforts, GenOMICC is the largest consented research study in the history of UK critical care medicine, leads the world in genetic discovery in Covid, and has found 25 genetic associations with critical illness. More importantly, it has already informed the selection of drugs in large scale clinical trials and continues to find new insights into the molecular mechanisms of disease. I have every confidence that, with your help, we will be able to do the same for other critical illness syndromes such as sepsis and influenza over the coming years.’

100,000 Genomes Projectupdate on BBC:

Hundreds of patients in gene study given rare disease diagnosis:

https://www.bbc.co.uk/news/health-59235573

NIHR Exeter CRF – UKCRF Symposium 2021

The theme of the UKCRF Symposium this year was Rapid Response, Reflections and Learning. Links to posters from CRF Staff will be made available in the coming weeks. One of the highlights from the event was a series of CRF compilation videos, which were great examples of how everyone involved in research stepped up to the mark and soldiered on through the pandemic.  If you’re interested in watching the videos please follow the links below.  The Exeter CRF Tissue Bank Team are featured in the second series: Adapting to the Pandemic.

1.             Celebrating CRF Success – https://youtu.be/XaiAk1K36ic

2.             Adapting to the Pandemic – https://youtu.be/ksMZMcM1Gys

3.             Looking in to the Future – https://youtu.be/rV3QtAVEyzY