Local project reference Project Short title Project Full title Recruitment end date
1002346 IMPACT Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls – The IMPACT study. 31/12/2018
1002349 UK TTP Registry United Kingdom Thrombotic Thrombocytopenic Purpura Registry: A prospective study of Thrombotic Thrombocytopenic Purpura in the UK 31/12/2018
1006384 UKAITPR United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid Conditions 12/06/2020
1113483 UKALL 14 A randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia 28/12/2018
1205649 ICON8 Trial Programme ICON8 and ICON8B – ICON8 Trial Programme (as per protocol v5 dated 17/12/2014) 01/07/2019
1207668 LI-1 Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial 13/07/2019
1207674 SEARCH A population based study of genetic predispositions and gene-environment interactions in cancer 30/09/2019
1210711 ESPAC-4 EUROPEAN STUDY GROUP FOR PANCREATIC CANCER – TRIAL 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers. 31/12/2018
1210712 INTERLACE A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer 01/12/2019
1301726 UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011 30/04/2019
1303754 OPTIMA Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis 31/01/2020
1303754b Optima (Main Trial) Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis 31/01/2020
1305779 IoN IoN Is ablative radio-iodine necessary for low risk differentiated thyroid cancer patients 01/02/2019
1311856 RAPPER Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy 31/03/2022
1408971 AML18 A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome 20/10/2020
1411013 FOCUS 4 FOCUS4 – Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trials programme 01/01/2019
1412029 IHCAP Investigating Hereditary Cancer Predisposition – a combined genomics approach 31/05/2020
1502056 The Molecular Investigation of Unexplained Anaemias The Molecular Investigation of Unexplained Anaemias and Related Congenital Anaemias 30/11/2023
1503071 FLAIR FLAIR: Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab 30/01/2020
1508136 MCL Biobank Observational Study Establishing a Biobank and Database as a National Resource for Characterising Indolent and Aggressive forms of Mantle Cell Lymphoma, an Observational Study. 30/10/2019
1601198 Add-Aspirin Trial A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours 01/08/2021
1603225 ACELARATE A phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patients with metastatic pancreatic carcinoma (ACELARATE: Acelarin first line randomised pancreatic study) 31/12/2020
1604237 SelPac SELPAC Uveal Melanoma Study 31/12/2018
1608296 APE Hartmann’s type procedure versus intersphincteric APE in patients undergoing resection of rectal cancer in whom restoration of gastrointestinal continuity is not appropriate: a multi centre, prospective observational study 30/06/2019
1610318 AML19 Adults with acute myeloid leukaemia or high-risk myelodysplastic syndrome 09/11/2021
1612350 INCA A multicentre randomised phase II clinical trial of Inotuzumab Ozogamicin plus Rituximab and CVP (IORCVP) versus Gemcitabine plus Rituximab and CVP (GemRCVP) for the first line treatment of patients with diffuse large B cell lymphoma who are not suitable for anthracycline containing chemotherapy 31/10/2018
1701365 The UK National Registry of Chronic Myeloid Leukaemia The UK National Registry of Chronic Myeloid Leukaemia 14/07/2020
1702374 Prepare-ABC Supportive Exercise Programmes for Accelerating Recovery after major Abdominal Cancer surgery (PREPARE-ABC) 01/05/2020
1703389 C31004 A Phase 2, Randomized Study of MLN0128 (a Dual TORC1/2 Inhibitor), MLN0128+MLN1117 (a PI3Kα Inhibitor), Weekly Paclitaxel, or the Combination of Weekly Paclitaxel and MLN0128 in Women With Advanced, Recurrent, or Persistent Endometrial Cancer 30/09/2018
1703390 CONCEPT CONCEPT: A Phase II pilot study of 3 weekly Cabazitaxel versus weekly Paclitaxel chemotherapy in the first line treatment of Her2 negative metastatic breast cancer (mBC) 31/12/2020
1703394 IMRiS IMRiS: Phase II study of IMRT in primary bone and soft tissue sarcoma 04/10/2018
1703398 CANC – 4658 A non-interventional biomarker study in patients with Non-Small Cell Lung Cancers (NSCLCs) of adenocarcinoma tumour histology treated in second line with nintedanib in combination with docetaxel 01/02/2019
1704403 TREATT A double blind, randomised controlled trial evaluating the safety and efficacy of Tranexamic acid in patients with haematological malignancies with severe thrombocytopenia 31/08/2019
1705427 Head & Neck 5000 Follow Up Study Head & Neck 5000 Follow Up Study 31/03/2019
1708470 plasmaMATCH plasmaMATCH – A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening 31/05/2019
1708476 TAMARIN Effects of TAMoxifen on the Mutant Allele Burden and Disease Course in Patients with MyeloprolifeRatIve Neoplasms 31/12/2018
1708490 PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers 24/01/2021
1710507 Niraparib in men with mCRPC and DNA repair anomalies A Phase 2 Efficacy and Safety Study of Niraparib in men with Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies 29/06/2019
1712540 CHRONOS-4 A Phase III, randomized, double-blind, controlled, multicenter study of intravenous
PI3K inhibitor copanlisib in combination with standard immunochemotherapy versus
standard immunochemotherapy in patients with relapsed indolent non-Hodgkin’s
lymphoma (iNHL) – CHRONOS-4
31/12/2019
1712541 Astellas AML Maintenance Study A Phase 3 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial of the FLT3 Inhibitor Gilteritinab (ASP2215) Administered as Maintenance Therapy Following Induction/Consolidation Therapy for Subjects with FLT3/ITD AML in First Complete Remission 14/03/2019
1802571 CR UK Stratified Medicine Pilot study The Cancer Research UK Stratified Medicine Programme: Pilot Study 31/12/2020
1802579 PRAN-16-52 PHASE III, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, RANDOMIZED STUDY OF PRACINOSTAT IN COMBINATION WITH AZACITIDINE IN PATIENTS ≥18 YEARS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA UNFIT FOR STANDARD INDUCTION CHEMOTHERAPY 30/12/2019
1804571 Open Label Study of Relugolix in Men with Advanced Prostate Cancer HERO: A Multinational Phase 3 Randomized, Open-label, Parallel Group Study to Evaluate the Safety and Efficacy of Relugolix in Men with Advanced Prostate Cancer 01/10/2018
1805626 LCH­-IV LCH-­IV ­International Collaborative Treatment Protocol for Children and
Adolescents with Langerhans Cell Histiocytosis
01/12/2020
1805629 MERU A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Subjects with Extensive Stage Small Cell Lung Cancer (MERU) 31/01/2019
1805632 National Lung Matrix National Lung Matrix Trial: Multi-­drug, genetic marker-directed, non­-comparative, multi-­centre, multi­-arm phase II trial in non-small cell lung cancer 01/10/2021
1810695 OPINION OPINION – A Phase IIIb, Single-arm, Open-label Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed non- Germline BRCA Mutated Ovarian Cancer Patients who are in Complete or Partial Response Following Platinum based Chemotherapy 30/03/2019
1810700 PLATO PLATO – PersonaLising Anal cancer radioTherapy dOse – Incorporating Anal Cancer Trials (ACT) ACT3, ACT4 and
ACT5
31/01/2022
1812731 B-AHEAD3 A randomised phase II trial of intermittent energy restriction and resistance exercise in women receiving chemotherapy for advanced breast cancer. 28/02/2020
1901749 CALLS A Cohort Study To Establish the Prevalence of Mutations in Patients with CML Who Meet the ELN Criteria for Warning or Failure and Patients With Ph+ALL With Detectable BCR-ABL1 Currently Being Treated With First or Subsequent TKI Therapy in the UK Using Next Generation Sequencing 31/12/2018
1902765 Ribociclib Non-Interventional Study Prospective observational study to describe effectiveness and socio-economic impact of ribociclib in clinical practice in the United Kingdom 29/06/2019
2003/7/145 NSCCG NSCCG – National Study of Colorectal Cancer Genetics 30/09/2018
604071 STAMPEDE Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy 31/12/2020
701001 UK Genetic Prostate Cancer Study UK Genetic Prostate Cancer Study 01/10/2019

Updated 17/09/2018