1008416 / British Association of Dermatologists Biologic Interventions Register

Molecular pathology of human genetic disease (Study due to close 31/07/2027)

1606263 / Comparison of Alitretinoin with PUVA as the first line treatment in patients with severe chronic hand eczema

The purpose of the ALPHA research study is to find out the most effective treatment for chronic hand eczema. The two most common treatments include exposure of hands to ultra violet (UV) light after they have been soaked in a solution called psoralen (a process referred to as PUVA) and a drug called Alitretinoin. Although both are equally used in standard clinical practice, there is no clear evidence indicating which of these two treatments is most effective. This study will compare these two treatments to examine both the short term and longer term effectiveness of each treatment in terms of how well the hands heal and how long the skin remains clear (minimal symptoms) once healed. Participants will receive the trial treatment for 12 weeks and up to 24 weeks depending on their response. Participants will then be followed up until week 52 (from start of treatment). Participants will be asked to return for assessments every 4 weeks up until week 52.

Selected hospitals recruiting to the study will take part in a sub study to find out whether there are any biological markers that are connected with a particular type of hand eczema. This information will provide insight into which group of patients respond best to which treatment. Detection of these biomarkers may, in future, enable doctors to more accurately diagnose the precise nature of hand eczema, which would enable better targeted treatment. There is evidence that individuals with mutations in a protein called Filaggrin are more susceptible to hand eczema. In this study a blood sample will be taken from all participants, DNA will be extracted from the blood sample in order to test whether the mutations are present. Anonymised samples of DNA will be placed into secure long term storage for potential future research. (Study due to close 31/12/2018)

1608291 / Multicenter Observational Prospective Study For The Identification Of Prognostic Factors In Patients With Mycosis Fungoides/Sezary Syndrome: Proposal For An International Prognostic Index For Cutaneous Lymphoma

A study of prognostic factors in cutaneous lymphoma with the aim of developing a prognostic index to identify high risk patients (Study due to close 02/07/2020)

1707457 / Effectiveness of an image analysing algorithm to diagnose melanoma compared to gold standard histological determination

Effectiveness of an image analysing algorithm to diagnose melanoma compared to gold standard histological determination (Study due to close 01/07/2018)